About LH / Lutropin
In both males and females, LH is essential for reproduction. In females, FSH initiates follicular growth and at the time of the maturation of the follicle, the estrogen rise leads to a release of LH over a 24-48 hour period. This "LH surge" triggers ovulation thereby not only releasing the egg, but also initiating the conversion of the residual follicle into a corpus luteum that, in turn, produces progesterone to prepare the endometrium for a possible implantation. LH is necessary to maintain luteal function for the first two weeks. In case of pregnancy luteal function will be further maintained by the action of hCG from the newly established pregnancy. In the male, LH acts upon the Leydig cells of the testis and is responsible for the production of testosterone.
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Scientific articles in which MedixMAB LH moclonals have been used
- Federici MM, Fraser R, Lundqvist C and Lankford JC (1982). Production and characterization of monoclonal antibodies human lutenizing hormones. Fed. Proc. 41.
- Haavisto A-M, Pettersson K, Bergendahl M, Perheentupa A, Roser JF and Huhtaniemi I (1993). A supersensitive immunofluorometric assay for rat luteinizing hormone. Endocrinol. 132(4): 1687-1691.
- Manna PR, Joshi L, Reinhold VN, Aubert ML, Suganuma N, Pettersson K and Huhtaniemi IT (2002). Synthesis, purification an structural and functional characterization of recombinant form of a common genetic variant of human luteinizing hormone. Hum. Mol. Gen. 11(3):301-315.
- Nilsson C, Seppälä M and Pettersson K (2001). Immunological characterization of human luteinizing hormone with special regard to a common genetic variant. J. Endocrinol. 168:10-116.
- Pettersson KSI and Söderholm JRM (1990). Ultrasensitive two-site immunometric assay of human lutropin by time-resolved fluorometry. Clin. Chem. 36(11):1928-1933.
- Pettersson KSI and Söderholm JRM (1991). Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies. Clin. Chem. 37(3):333-340.
- Vilja P, Wichmann L, Isola J and Tuohimaa P (1988). Monoclonal-antibody based noncompetitive avidin-biotin assay for lutropin in urine. Clin. Chem. 34(8):1585-1590.
- Yano K, Hashida S, Okuno A and Ishikawa E (1988). Serum concentration of chorionic gonadotropin-like substance and luteinizing hormone in children measured by sensitive enzyme immunoassay. J. Clin. Lab. Anal., 2:220-224