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MedixMAB Immunoglobulin M (IgM)

Specifications for Anti-human Immunoglobulin M (IgM):

About IgM / Immunoglobulin M

Immunoglobulin M (IgM) is a basic antibody that is present on B cells. It is the first antibody to appear in response to initial exposure to antigen.  IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer.  Demonstrating IgM antibodies in a patient's serum indicates recent infection, or in a neonate's serum indicates intrauterine infection (e.g. congenital rubella).

Product Specification Sheets 

Product name   

Product Code

Product Specification Sheet

  • Anti-h IgM clone 7408

100084

 

Scientific articles in which MedixMAB IgM monoclonals have been used

 
  • Juhela S, Hyöty H, Lönnrot M, Roivainen M, Simell O and Ilonen J (1998). Enterovirus infections and enterovirus specific T-cell responses in infancy. J. Med. Virol., 54:226-232.
  • Juhela S, Hyöty H, Hinkkanen A, Elliott J, Roivainen M, Kulmala P, Rahko J, Knip M and Ilonen J (1999). T cell responses to enterovirus antigens and to b-cell autoantigens in unaffected children positive for IDDM-associated autoantibodies. J. Autoimmun. 12:269-278. 
  • Hiltunen M, Hyöty H, Knip M, Ilonen J, Reijonen H, Vähäsalo P, Roivainen R, Lönnrot M, Leinikki P, Hovi T, Åkerblom HK and the Childhood Diabetes in Finland Group (DiMe) study Group (1997). Islet cell antibody seroconversion in children is temporally associated with enterovirus infections. J. Inf. Dis. 175:554-560. 
  • Hyöty H, Hiltunen M, Knip M, Laakkonen M, Vähäsalo P, Karjalainen J, Koskela P, Roivainen M, Leinikki P, Hovi T, Åkerblom HK and the Childhood Diabetes in Finland (DiMe) Study Group (1995). A prospective study of the role of Coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Diabetes 44:652-657. 
  • Lönnrot M, Knip M, Roivainen M, Koskela P, Åkerblom HK and Hyöty H (1998). Onset of type 1 diabetes mellitus in infancy after enterovirus infcetions. Diabetic Med, 15:431-434 
  • Valtanen S, Roivainen M and Hovi T (1999). Problems with biotin-labelled virions as probes in poliovirus-specific m-capture-IgM assays. J. Clin. Virol. 14:17-23. 
  • Viskari HR, Roivainen M, Reunanen A, Pitkäniemi J, Sadeharju K, Koskela P, Hovi T, Leinikki P, Vilja P, Tuomilehto J and Hyöty H (2002). Materal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus. Diabet. 51:2568-2571

 

 

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