Actim PROM

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Fetal membranes ruptured or not?

The Actim PROM rapid test reliably detects premature rupture of fetal membranes (PROM). Since PROM accounts for approximately 10% of all prenatal deaths, truly reliable diagnosis is essential to ensure the wellbeing of both mother and child. Even microruptures need to be detected, since they predispose both fetus and mother to infections.

Actim PROM is a fast immunochromatographic dipstick test that reacts to the presence of amniotic fluid in vaginal and cervical secretions. Based on monoclonal antibodies, the Actim PROM test detects IGFBP-1 (insulin-like growth factor binding protein-1) in a vaginal or cervical sample.

A reliable and simple point-of-care test


Since the concentration of IGFBP-1 is several decades higher in amniotic fluid than in other body fluids, finding IGFBP-1 in the vaginal or cervical sample reliably indicates a membrane rupture. Numerous studies have shown that the diagnosis of PROM by detection of IGFBP-1 is the most reliable method, and therefore superior to other chemical, clinical and immunological methods available today.

The Actim PROM dipstick test can be performed quickly and simply by taking a vaginal or cervical secretion sample, extracting it and immersing the dipstick in a solution of the extraction.


Results are clearly visible in 5 minutes


A positive result appears as two blue lines – a control line and a test line – in the result area. If only the control line appears after five minutes, the test result is negative.

Actim PROM is not currently available in the US.