MedixMAB™ antibodies & MedixAntigens™

Diabetes & Metabolism

Adiponectin

Adiponectin is a protein hormone that modulates a number of metabolic processes that may lead to type 2 diabetes, obesity, atherosclerosis, and non-alcoholic fatty liver disease.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human adiponectin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100255
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.4 – 8.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 3 x 105 1/Ms
    Dissociation rate constant 2 x 10-4 1/s
    Affinity constant KA = 1 x 109 1/M; KD = 8.5 x 10-10 M (= 0.85 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human adiponectin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100256
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.1 – 8.5
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant 3 x 105 1/Ms
    Dissociation rate constant 2 x 10-4 1/s
    Affinity constant KA = 2 x 109 1/M; KD = 6 x 10-10 M (= 0.6 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human adiponectin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100257
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.1 – 8.7
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant 3 x 105 1/Ms
    Dissociation rate constant 2 x 10-4 1/s
    Affinity constant KA = 2 x 109 1/M; KD = 6 x 10-10 M (= 0.6 nM)

Recombinant Antigens

Albumin

Albumin normally constitutes about 60% of human plasma proteins and is produced in the liver. It is important in regulating blood volume, and also serves as carriers for molecules in blood.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human albumin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100749
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 109 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human albumin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100064
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 2.5 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 9.2
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not Determined (N/D)

ApoA1

Apolipoprotein A1 (ApoA1) is a major component of the high-density lipoprotein (HDL). ApoA1 helps clear cholesterol from arteries. ApoA1 has been suggested as a better indicator of coronary artery disease than HDL.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human apolipoprotein A1 (ApoA1)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100263
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2 x 105 1/Ms
    Dissociation rate constant 5 x 10-4 1/s
    Affinity constant KA = 5 x 108 1/M; KD = 2 x 10-9 M
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human apolipoprotein A1 (ApoA1)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100264
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 8 x 105 1/Ms
    Dissociation rate constant 8 x 10-4 1/s
    Affinity constant KA = 1 x 109 1/M; KD = 1 x 10-9 M

Recombinant Antigens

ApoB

Apolipoprotein B (ApoB) is the primary apolipoprotein of low-density lipoprotein (LDL), which is responsible for carrying cholesterol to tissues. High levels of ApoB can lead to plaques that cause atherosclerosis.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human apolipoprotein B (ApoB)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100261
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

C-peptide

C-peptide is produced along with insulin when proinsulin is split. C-peptide can be used to help determine how much insulin the patient’s pancreas is still producing.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-peptide
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100113
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-peptide
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100114
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D

Ferritin

Ferritin binds and stores iron, preventing iron deficiency (anemia) and iron overload (hemochromatosis). The amount of ferritin in the serum is measured in relation to some chronic diseases and anemia.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human ferritin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100111
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.3
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human ferritin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100112
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol

HbA1c

Glycated hemoglobin (HbA1c) is primarily measured to identify the average plasma glucose concentration over prolonged periods of time. Higher levels are found in people with persistently elevated blood sugar, as in diabetes.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human glycated hemoglobin A1
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100301
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

Insulin

Insulin is a peptide hormone produced in the pancreas by beta cells. It is formed as a precursor molecule preproinsulin, which is first cleaved into proinsulin, and later to mature insulin. Insulin is important for carbohydrate and fat metabolism and its deficiency leads to diabetes mellitus.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human insulin
    Description Monoclonal antibody raised against human Insulin. In vitro cultured mouse monoclonal antibody.     
    Product code 700013
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA when Anti-h Insulin antibody 9350 was used as a detection antibody
    IEF profile 6.8 - 7.2     
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human insulin
    Description Monoclonal antibody raised against human Insulin. In vitro cultured mouse monoclonal antibody.
    Product code 700014
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA when Anti-h Insulin antibody 9351 was used as a capture antibody
    IEF profile 6.8 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant N/D

Lactoferrin

Lactoferrin is an antimicrobial protein, also known as lactotransferrin, which transfers iron to the cells. It is used in a faecal test to detect inflammation in the intestine. Lactoferrin levels are associated with disease severity in inflammatory bowel disease (IBD).

Recombinant Antigens

Renin

Renin is a proteolytic enzyme secreted by the kidneys that is involved in the release of angiotensin and regulation of sodium and potassium balance. Renin is measured to diagnose primary aldosteronism and hypertension.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human renin
    Description Monoclonal antibody raised against human renin. In vitro cultured mouse hybridomas.
    Product code 700025
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative     
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA when Anti-h Renin antibody 10850 was used as a detection antibody
    IEF profile Not Determined (N/D)
    Purity N/D
    Subclass IgG1
    Association rate constant N/D
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human renin
    Description Monoclonal antibody raised against human renin. In vitro cultured mouse hybridomas.
    Product code 700026
    Product buffer solution 0.1 M BBS, pH 8, 0.9 % NaCl      
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA when Anti-h Renin antibody 10851 was used as a capture antibody
    IEF profile Not Determined (N/D)
    Purity N/D
    Subclass IgG1
    Association rate constant N/D
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human renin
    Description Monoclonal antibody raised against human renin. In vitro cultured mouse hybridomas.
    Product code 700030
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative      
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA
    IEF profile Not Determined (N/D)
    Purity N/D
    Subclass IgG1
    Association rate constant N/D
    Dissociation rate constant N/D
    Affinity constant N/D

Transferrin

Transferrin regulates the amount of free iron in circulation. Transferrin concentration is elevated in anemia, but can also be used to diagnose other clinical conditions.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100525
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 0.6 x 106 1/Ms
    Dissociation rate constant 1.7 x 10-4 1/s
    Affinity constant KA = 3.8 x 109 1/M; KD = 2.6 x 10-10 M (=0.26 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100440
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 - 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.7 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-5 1/s
    Affinity constant KA = 5.3 x 1011 1/M; KD = 1.9 x 10-12 M (=0.002 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100474
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.4 – 8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 2.2 x 106 1/Ms
    Dissociation rate constant 1.1 x 10-4 1/s
    Affinity constant KA = 2.1 x 1010 1/M; KD = 4.8 x 10-11 M (=0.048 nM)

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