MedixMAB™ antibodies & MedixAntigens™

Hormones

Hormones technical note

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Hormones are signalling molecules secreted by glands (endocrine signalling system) for communication between organs and tissues for physiological regulation and behaviour. They affect their target cells by binding to a specific receptor to activate a signal transduction pathway. Upon secretion, certain hormones are water-soluble and are readily transported through the circulatory system, while others are lipid-soluble and need transportation through carrier plasma glycoproteins.

Alpha subunit

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100035
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °CAnalyte descriptionThe alpha subunits of gonadotropins LH, FSH, TSH, and hCG are identical. The human alpha subunit consists of 92 amino acids, and has an average molecular weight of 14 kDa.
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.9 x 106 1/Ms
    Dissociation rate constant 1.1 x 10-3
    Affinity constant KA = 1.7 x 109 1/M; KD = 5.7 x 10-10 M (= 0.57 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100037
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 6 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.0 – 8.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.7 x 106
    Dissociation rate constant 5.3 x 10-4
    Affinity constant KA = 3.2 x 109 1/M; KD = 3.2 x 10-10 M (= 0.32 nM)     
    Type Monoclonal Antibodies
    Specificity Antibody recognizes the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100066
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.4
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 8.9 x 105
    Dissociation rate constant 3.8 x 10-5
    Affinity constant KA = 2.4 x 109 1/M; KD = 4.2 x 10-11 M (= 0.04 nM)

hCG

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100004
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 - 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 2.0 x 106 1/Ms and hCGβ: 5.0 x 105 1/Ms
    Dissociation rate constant hCG: 3.7 x 10-5 1/s and hCGβ: 1.2 x 10-4 1/s
    Affinity constant hCG: KA = 5.3 x 1010 1/M; KD = 1.9 x 10-11 M (= 0.02 nM)hCGβ: KA = 4.3 x 109 1/M; KD = 2.3 x 10-10 M (= 0.23 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100005
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 5.7 x 106 1/Ms and hCGβ: 2.3 x 106 1/Ms
    Dissociation rate constant hCG: 2.9 x 10-4 1/s and hCGβ: 4.8 x 10-4
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100006
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 8.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 4.0 x 106 1/Ms and hCGβ: 1.6 x 106
    Dissociation rate constant hCG: 1.4 x 10-4 1/s and hCGβ: 3.6 x 10-4
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100008
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.1 x 106 1/Ms
    Dissociation rate constant 3.1 x 10-4 1/s
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100368     
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.1 x 104 1/Ms
    Dissociation rate constant 1.7 x 10-4
    Affinity constant KA = 1.2 x 109 1/M; KD = 8.1 x 10-10 M (= 0.81 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100009
    Product buffer solution 29 mM citrate, 142 mM phosphate, pH 6.5, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 2.4 x 106 1/Ms and hCGβ: 1.9 x 106
    Dissociation rate constant hCG: 4.4 x 10-4 1/s and hCGβ: 1.1 x 10-3
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100011
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 2.5 x 105 1/Ms and hCGβ: 2.8 x 105
    Dissociation rate constant hCG: 1.5 x 10-4 1/s and hCGβ: 2.8 x 10-4
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human chorionic gonadotropin and its free beta subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100013
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant hCG: 1.5 x 106 1/Ms and hCGβ: 1.9 x 106
    Dissociation rate constant hCG: 9.5 x 10-4 1/s and hCGβ: 5.2 x 10-3

FSH

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human follicle-stimulating hormone (FSH)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100067
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol

Estradiol

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human estradiol (E2)
    Description Monoclonal antibody raised against human 17b Estradiol. In vitro cultured mouse monoclonal antibody.
    Product code 700011
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Not Determined (N/D)
    IEF profile N/D
    Purity N/D
    Subclass IgG1
    Association rate constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human estradiol (E2)
    Description Monoclonal antibody raised against human 17b Estradiol. In vitro cultured mouse monoclonal antibody.
    Product code 700012
    Product buffer solution 0.1 M PBS, pH 7.4, 0.9 % NaCl, 0.05 % NaN3 as a preservative
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1 mg/ml
    Immunoreactivity Not Determined (N/D)
    IEF profile N/D
    Purity N/D
    Subclass IgG1
    Association rate constant N/D

Synthetic Antigens

Growth hormone

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human growth hormone (GH)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100041     
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 2 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human growth hormone (GH)     
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100042     
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 1010 l/mol

LH

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human luteinizing hormone (lutropin), and its beta-subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100016
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 5.8 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-5 1/s
    Affinity constant KA = 4.4 x 1011 1/M; KD = 2.3 x 10-12 M (= 2.3 pM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human luteinizing hormone (lutropin), and its beta-subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100018
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.6 – 6.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.3 x 106 1/Ms
    Dissociation rate constant 2.6 x 10-5 1/s
    Affinity constant KA = 4.8 x 1010 1/M; KD = 2.1 x 10-11 M (= 21 pM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human luteinizing hormone (lutropin)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100588
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 5.4 x 106 1/Ms
    Dissociation rate constant 3.4 x 10-5 1/s
    Affinity constant KA = 1.6 x 1011 1/M; KD = 6.3 x 10-12 M (= 6.3 pM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human luteinizing hormone (lutropin), and its beta-subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100022
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 – 6.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.7 x 106 1/Ms
    Dissociation rate constant 1.6 x 10-5 1/s
    Affinity constant KA = 2.9 x 1011 1/M; KD = 3.4 x 10-12 M (= 3.4 pM)

Progesterone

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes progesterone
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100248
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05% Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes progesterone
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100249
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.4 – 8.6
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes progesterone
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100250
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.5
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes progesterone
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100252
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 8.2
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

PRL

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human prolactin (luteotropic hormone, or luteotropin)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100038
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 2.6 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human prolactin (luteotropic hormone, or luteotropin)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100360
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 9.5 x 109 l/mol

SHBG

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human sex hormone-binding globulin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100539
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant kon = 4.1 x 105 1/Ms
    Dissociation rate constant koff = 4.7 x 10-5 1/s
    Affinity constant KA = 8.8 x 109 1/M; KD = 1.2 x 10-10 M (=0.12 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human sex hormone-binding globulin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100540
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant kon = 1.5 x 105 1/Ms
    Dissociation rate constant koff = 1.0 x 10-4 1/s
    Affinity constant KA = 1.5 x 109 1/M; KD = 6.8 x 10-10 M (=0.68 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human sex hormone-binding globulin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100569
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D

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