MedixMAB™ antibodies & MedixAntigens™

Inflammation

Technical Note Inflammation

Technical Note Inflammation Medix Biochemica (upated 06/2020)

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Inflammation is the body’s generic response to pathogens, irritants, or damaged cells, and it is considered a hallmark of the innate immune response. Its function is to eliminate the initial causes of cell damage, to remove necrotic cells and tissues and to initiate tissue repair. The increased supply of neutrophils and macrophages assist in the process. Subdued inflammation could lead to progressive tissue destruction caused by the harmful stimulus. Persistent, chronic inflammation leads to a shift in cell types such as mononuclear cells at the inflammation site, and may lead to diseases like allergies, atherosclerosis, cancer, neurodegenerative or autoimmune diseases.

AAT

Alpha 1-antitrypsin (AAT) is a glycoprotein, generally known as serum trypsin inhibitor, that protects the lungs from the destructive actions of blood enzymes. Disorders of this protein include AAT-deficiency, a hereditary condition leading to a chronic uninhibited tissue breakdown.

Monoclonal Antibodies

    Anti-h AAT 1002 SPTN-5 100209 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha 1-antitrypsin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100209
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7–7.7
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h AAT 1003 SPTN-5 100210 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha 1-antitrypsin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100210
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7–7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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CRP

C-reactive protein (CRP) is a protein found in the blood, whose rise in response to inflammation. CRP values are useful in determining disease progress or the effectiveness of treatments.

Monoclonal Antibodies

    Anti-h CRP 6402 SPTN-5 100145 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100145
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6–7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.3 x 105 1/Ms
    Dissociation rate constant 1.2 x 10-4 1/s
    Affinity constant KA = 6.2 x 109 1/M; KD = 1.6 x 10-10 M (= 0.16 nM)
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    Anti-h CRP 6403 SPTN-5 100146 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100146
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9–6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 9.6 x 105 1/Ms
    Dissociation rate constant 1.6 x 10-4 1/s
    Affinity constant KA = 6.2 x 109 1/M; KD = 1.6 x 10-10 M (= 0.16 nM)
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    Anti-h CRP 6404 SP-2 100058 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100058
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 2.0–2.5 mg/ml
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7–6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.7 x 106 1/Ms
    Dissociation rate constant 4.1 x 10-4 1/s
    Affinity constant KA = 1.4 x 1010 1/M; KD = 5.3 x 10-11 M (= 0.05 nM)
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    Anti-h CRP 6404 SP-6 100061 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100061
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration > 6 mg/ml
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7–6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.7 x 106 1/Ms
    Dissociation rate constant 4.1 x 10-4 1/s
    Affinity constant KA = 1.4 x 1010 1/M; KD = 5.3 x 10-11 M (= 0.05 nM)
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    Anti-h CRP 6405 SPTN-5 100358 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100358
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8–7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.6 x 106 1/Ms
    Dissociation rate constant 6.6 x 10-5 1/s
    Affinity constant KA = 3.9 x 1010 1/M; KD = 2.6 x 10-11 M (= 0.03 nM)
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    Anti-h CRP 6407 SPTN-5 100147 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100147
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5–7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.1 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-4 1/s
    Affinity constant KA = 8.9 x 109 1/M; KD = 1.1 x 10-10 M (= 0.11 nM)
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Calprotectin

Calprotectin belongs to the family of S100 proteins and is composed of two subunits S100A8 and S100A9. Increased concentrations are found in response to infections and inflammation.

Calprotectin leaflet

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Monoclonal Antibodies

    Anti-h Calprotectin 3403 SPTN-5 100460 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A9 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100460
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.2–8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 1.9 x 106 1/Ms
    Dissociation rate constant 9.1 x 10-4 1/s
    Affinity constant KA = 2.1 x 109 1/M; KD = 4.8 x 10-10 M (= 0.48 nM)
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    Anti-h Calprotectin 3404 SPTN-5 100468 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100468
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3–7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.8 x 105 1/Ms
    Dissociation rate constant 6.1 x 10-5 1/s
    Affinity constant KA = 7.8 x 109 1/M; KD = 1.3 x 10-10 M (=0.13 nM)
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    Anti-h Calprotectin 3405 SPTN-5 100469 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100469
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.4–7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.4 x 105 1/Ms
    Dissociation rate constant 1.5 x 10-4 1/s
    Affinity constant KA = 5.0 x 109 1/M; KD = 2.0 x 10-10 M (= 0.2 nM)
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    Anti-h Calprotectin 3406 SPTN-5 100470 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100470
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8–7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.6 x 105 1/Ms
    Dissociation rate constant 1.1 x 10-4 1/s
    Affinity constant KA = 6.9 x 109 1/M; KD = 1.4 x 10-10 M (=0.14 nM)
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    Anti-h Calprotectin 3407 SPTN-5 100618 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8/S100A9 complex
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100618
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8–7.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.0 x 104 1/Ms
    Dissociation rate constant 5.0 x 10-5 1/s
    Affinity constant KA = 8.0 x 108 1/M; KD = 1.3 x 10-9 M (=1.3 nM)
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Recombinant Antigens

    Recombinant Calprotectin antigen, 100 μg 610061 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human calprotectin heterotetramer (S100A8/S100A9) protein with an N-terminal histidine tag in the S100A8 subunit. Predicted molecular weights: S100A8 12 kDa, S100A9 13 kDa.
    Product code 610061
    Shelf life and storage 24 months for lyophilized product, storage at 2-8 °C. After reconstitution 1 month at 2-8 °C and 1 month at -20 °C. Reconstituted product is recommended to be stored in plastic (PP) containers.
    Product concentration 0.5 mg/ml when reconstituted with 200 µl of deionized water
    Purity Capillary electrophoresis (CE-SDS)
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    Recombinant Calprotectin S100A8, 50 µg 710018 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A8 antigen is produced by E.coli expression system and the target gene encoding Met1-Glu93 is expressed with a 6His tag at the C-terminus. Predicted molecular weight: 14 kDa.     
    Product code 710018
    Product concentration 0.5 mg/ml when reconstituted with 100 µl of deionized water 
    Purity SDS-PAGE > 90 %
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    Recombinant Calprotectin S100A8, 500 µg 710035 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A8 antigen is produced by E.coli expression system and the target gene encoding Met1-Glu93 is expressed with a 6His tag at the C-terminus. Predicted molecular weight: 14 kDa.
    Product code 710035
    Product buffer solution 20 mM HEPES, pH 7.4, 150 mM NaCl
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 1000 µl of deionized water
    Purity SDS-PAGE > 90 %
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    Recombinant Calprotectin S100A8, 1000 µg 710034 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A8 antigen is produced by E.coli expression system and the target gene encoding Met1-Glu93 is expressed with a 6His tag at the C-terminus. Predicted molecular weight: 14 kDa.  
    Product code 710034
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 2000 µl of deionized water
    Purity SDS-PAGE > 90 %
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    Recombinant Calprotectin S100A9, 50 µg 710019 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A9 antigen is produced by E.coli expression system and the target gene encoding Thr2-Pro114 is expressed. Predicted molecular weight: 13 kDa.
    Product code 710019
    Product concentration 0.5 mg/ml when reconstituted with 100 µl of deionized water
    Purity SDS-PAGE > 90 %
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    Recombinant Calprotectin S100A9, 500 µg 710037 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A9 antigen is produced by E.coli expression system and the target gene encoding Thr2-Pro114 is expressed. Predicted molecular weight: 13 kDa.
    Product code 710037
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 1000 µl of deionized water     
    Purity SDS-PAGE > 90 %    
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    Recombinant Calprotectin S100A9, 1000 µg 710036 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein A9 antigen is produced by E.coli expression system and the target gene encoding Thr2-Pro114 is expressed. Predicted molecular weight: 13 kDa.
    Product code 710036
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 2000 µl of deionized water     
    Purity SDS-PAGE > 90 %         
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IL-6

Interleukin-6 (IL-6) acts as both pro-inflammatory and anti-inflammatory cytokine. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer’s Disease, cancer, and rheumatoid arthritis.

Monoclonal Antibodies

    Anti-h IL-6 2703 SPTN-5 100328 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100328
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3–7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.0 x 105 1/Ms
    Dissociation rate constant 5.6 x 10-5 1/s
    Affinity constant KA = 1.8 x 109 1/M; KD = 5.6 x 10-10 M (=0.56 nM)
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    Anti-h IL-6 2704 SPTN-5 100329 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100329
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4–7.5
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant 1.9 x 105 1/Ms
    Dissociation rate constant 1.7 x 10-4 1/s
    Affinity constant KA = 1.1 x 109 1/M; KD = 9.2 x 10-10 M (=0.92 nM)
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    Anti-h IL-6 2706 SPTN-5 100330 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100330
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.1–7.9
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 3.6 x 104 1/Ms
    Dissociation rate constant 1.5 x 10-5 1/s
    Affinity constant KA = 2.5 x 109 1/M; KD = 4.1 x 10-10 M (=0.41 nM)
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    Anti-h IL-6 2707 SPTN-5 100798 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100798
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9–6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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Recombinant Antigens

    Recombinant IL-6, 50 µg 710015 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human interleukin-6 antigen is produced by E.coli expression system and the target gene encoding Pro29-Met212 is expressed. Predicted molecular weight: 19 kDa.
    Product code 710015
    Shelf life and storage Unspecified, storage at -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 100 µl of deionized water
    Purity SDS-PAGE > 90 %
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    Recombinant IL-6, 500 µg 710039 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human interleukin-6 antigen is produced by E.coli expression system and the target gene encoding Pro29-Met212 is expressed. Predicted molecular weight: 19 kDa.
    Product code 710039
    Shelf life and storage Unspecified, storage at -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 1000 µl of deionized water
    Purity SDS-PAGE > 90 %
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    Recombinant IL-6, 1000 µg 710038 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human interleukin-6 antigen is produced by E.coli expression system and the target gene encoding Pro29-Met212 is expressed. Predicted molecular weight: 19 kDa.
    Product code 710038
    Shelf life and storage Unspecified, storage at -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 2000 µl of deionized water
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IL-8

Interleukin-8 (IL-8) is a chemokine which serves as a chemical signal that attracts neutrophils at the site of inflammation. IL-8 is a promising marker for many clinical conditions with inflammation.

Monoclonal Antibodies

    Anti-h IL-8 1501 SPTN-5 100218 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-8
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100218
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3–7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 3 x 105 1/Ms
    Dissociation rate constant 2 x 10-3 1/s
    Affinity constant KA = 2 x 108 1/M ; KD = 5 x 10-9 M
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Lactoferrin

Lactoferrin is an antimicrobial protein, also known as lactotransferrin, which transfers iron to the cells. It is used in fecal testing to detect inflammation in the intestine. Lactoferrin levels are associated with disease severity in inflammatory bowel disease (IBD).

Recombinant Antigens

NGAL

Neutrophil gelatinase-associated lipocalin (NGAL) also known as lipocalin-2, is used as a biomarker of kidney injury, and has also been shown to play a role in cancer and cardiovascular events.

Monoclonal Antibodies

    Anti-h NGAL 4202 SPTN-5 100579 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100579
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8–7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.4 x 105 1/Ms
    Dissociation rate constant 4.0 x 10-4 1/s
    Affinity constant KA = 1.6 x 109 1/Ms; KD = 6.3 x 10-10 M (0.63 nM)
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    Anti-h NGAL 4203 SPTN-5 100580 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100580
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3–7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.2 x 105 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
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    Anti-h NGAL 4204 SPTN-5 100581 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100581
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0–7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.8 x 105 1/Ms
    Dissociation rate constant 3.4 x 10-5 1/s
    Affinity constant KA = 5.3 x 109 1/M; KD = 1.8 x 10-10 M (= 0.18 nM)
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    Anti-h NGAL 4205 SPTN-5 100582 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100582
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0–7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 5.6 x 104 1/Ms
    Dissociation rate constant 4.9 x 10-5 1/s
    Affinity constant KA = 1.2 x 109 1/M; KD = 8.6 x 10-10 M (= 0.86 nM)
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Recombinant Antigens

PCT

Procalcitonin (PCT) is a precursor protein of the hormone calcitonin, and is associated with systemic infections. In clinical diagnostics, a PCT test is most often used to identify patients with sepsis.

Monoclonal Antibodies

    Anti-h Calcitonin 4051 700020 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human calcitonin and procalcitonin
    Description Monoclonal antibody raised against human calcitonin. In vitro cultured mouse hybridomas.
    Product code 700020
    Product buffer solution 0.1 M BBS, pH 8, 0.9 % NaCl
    Shelf life and storage 60 months from manufacturing at 2 – 8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Not Determined (N/D)
    IEF profile 6.0 – 6.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant N/D
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h PCT 4003 SPTN-5 100562 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100562
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4–6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.8 x 104 1/Ms
    Dissociation rate constant 2.2 x 10-4 1/s
    Affinity constant KA = 2.2. x 108 1/M; KD = 4.6 x 10-9 M (=4.6 nM)
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    Anti-h PCT 4004 SPTN-5 100563 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100563
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2–6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.5 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
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    Anti-h PCT 4005 SPTN-5 100564 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100564
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0–6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.9 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
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    Anti-h PCT 4006 SPTN-5 100567 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100567
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3–7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.7 x 104 1/Ms
    Dissociation rate constant 3.5 x 10-4 1/s
    Affinity constant KA = 1.9 x 108 1/M; KD = 5.2 x 10-9 M (=5.2 nM)
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    Anti-h PCT 4008 SPTN-5 100769 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100769
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 8.2–9.1
    Purity ≥ 95 %
    Subclass IgG3
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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Recombinant Antigens

    Recombinant PCT antigen, 100 μg 610080 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human procalcitonin (PCT) protein with a C-terminal histidine tag. Predicted molecular weight: 14 kDa
    Product code 610080
    Shelf life and storage Unspecified for lyophilized product, storage at 2-8 °C. After reconstitution 1 week at 2-8 °C and 10 months at - 20 °C.
    Product concentration 0.5 mg/ml when reconstituted with 200 µl of deionized water
    Purity Capillary electrophoresis (CE-SDS)
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Serum Amyloid A

Serum amyloid A (SAA) is associated with HDL during inflammatory states. The blood level of SAA increases dramatically in response to tissue injury and inflammation.

Monoclonal Antibodies

    Anti-h SAA 2201 SPTN-5 100279 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100279
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.4 – 8.8
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 1.9 x 105 1/Ms
    Dissociation rate constant 1.8 x 10-4 1/s
    Affinity constant KA = 1.0 x 109 1/M; KD = 9.6 x 10-10 M (= 1.0 nM)
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    Anti-h SAA 2203 SPTN-5 100289 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100289
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.1 x 105 1/Ms
    Dissociation rate constant 3.0 x 10-4 1/s
    Affinity constant KA = 3.5 x 108 1/M; KD = 2.8 x 10-9 M (= 2.8 nM)
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    Anti-h SAA 2205 SPTN-5 New 100802 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100802
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h SAA 2208 SPTN-5 New 100805 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100805
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h SAA 2209 SPTN-5 New 100806 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100806
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5–7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h SAA 2211 SPTN-5 New 100808 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100808
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h SAA 2212 SPTN-5 New 100809 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100809
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.2 – 7.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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    Anti-h SAA 2213 SPTN-5 New 100810 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100810
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.3 – 8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
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Recombinant Antigens

    Recombinant SAA antigen, 100 µg 610070 Specifications (pdf) Request sample
    Type Recombinant Antigens
    Description Recombinant human serum amyloid A (SAA) protein with an N-terminal histidine tag. Predicted molecular weight: 14 kD
    Product code 610070
    Shelf life and storage Unspecified for lyophilized product, storage at 2-8 °C. After reconstitution 1 month at 2-8°C and 1 month at -20°C.
    Product concentration 0.5 mg/ml when reconstituted with 200 µl of deionized water
    Purity Capillary electrophoresis (CE-SDS)
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Transferrin

Transferrin regulates the amount of free iron in circulation. Transferrin concentration elevates in anemia, and can also be used to diagnose other clinical conditions.

Monoclonal Antibodies

    Anti-h Transferrin 3104 SPTN-5 100525 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100525
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7–7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 0.6 x 106 1/Ms
    Dissociation rate constant 1.7 x 10-4 1/s
    Affinity constant KA = 3.8 x 109 1/M; KD = 2.6 x 10-10 M (=0.26 nM)
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    Anti-h Transferrin 3105 SPTN-5 100440 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100440
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5–7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.7 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-5 1/s
    Affinity constant KA = 5.3 x 1011 1/M; KD = 1.9 x 10-12 M (=0.002 nM)
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    Anti-h Transferrin 3106 SPTN-5 100474 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100474
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2–8.5
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 2.2 x 106 1/Ms
    Dissociation rate constant 1.1 x 10-4 1/s
    Affinity constant KA = 2.1 x 1010 1/M; KD = 4.8 x 10-11 M (=0.048 nM)
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Trypsinogen-2

Trypsinogen-2 is the precursor form of the pancreatic enzyme trypsin. Determination of urine trypsinogen-2 is a useful test to detect acute pancreatitis and to evaluate disease severity.

Monoclonal Antibodies

    Anti-h Trypsinogen-2 8603 SPRN-5 100107 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human trypsinogen-2
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100107
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6–7.6
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.4 x 108 1/M
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    Anti-h Trypsinogen-2 8607 SPTN-5 100108 Specifications (pdf) Request sample
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human trypsinogen-2
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components.
    Product code 100108
    Product buffer solution 50 mM Na-citrate, pH 7.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0–6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.6 x 108 1/M
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