MedixMAB™ antibodies & MedixAntigens™

Inflammation

MedixMAB™ Inflammation techical note

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Inflammation is the body’s generic response to pathogens, irritants, or damaged cells, and it is considered a hallmark of the innate immune response. Its function is to eliminate the initial causes of cell damage, to remove necrotic cells and tissues and to initiate tissue repair. The increased supply of neutrophils and macrophages assist in the process. Subdued inflammation could lead to progressive tissue destruction caused by the harmful stimulus. Persistent, chronic inflammation leads to a shift in cell types such as mononuclear cells at the inflammation site, and may lead to diseases like allergies, atherosclerosis, cancer, neurodegenerative or autoimmune diseases.

AAT

Alpha 1-antitrypsin (AAT) is a glycoprotein, generally known as serum trypsin inhibitor, that protects the lungs from the destructive actions of blood enzymes. Disorders of this protein include AAT-deficiency, a hereditary condition leading to a chronic uninhibited tissue breakdown.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha 1-antitrypsin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100209
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.7
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha 1-antitrypsin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100210
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

CRP

C-reactive protein (CRP) is a protein found in the blood, whose rise in response to inflammation. CRP values are useful in determining disease progress or the effectiveness of treatments.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100145
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/– 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.3 x 105 1/Ms
    Dissociation rate constant 1.2 x 10-4 1/s
    Affinity constant KA = 6.2 x 109 1/M; KD = 1.6 x 10-10 M (= 0.16 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100146
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/– 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 9.6 x 105 1/Ms
    Dissociation rate constant 1.6 x 10-4 1/s
    Affinity constant KA = 6.2 x 109 1/M; KD = 1.6 x 10-10 M (= 0.16 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100058
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 2.0-2.5 mg/ml
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.7 x 106 1/Ms
    Dissociation rate constant 4.1 x 10-4 1/s
    Affinity constant KA = 1.4 x 1010 1/M; KD = 5.3 x 10-11 M (= 0.05 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100061
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration > 6 mg/ml
    Immunoreactivity 80–120 % compared to the reference sample in an FIA tests
    IEF profile 5.7 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.7 x 106 1/Ms
    Dissociation rate constant 4.1 x 10-4 1/s
    Affinity constant KA = 1.4 x 1010 1/M; KD = 5.3 x 10-11 M (= 0.05 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100358
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/– 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.6 x 106 1/Ms
    Dissociation rate constant 6.6 x 10-5 1/s
    Affinity constant KA = 3.9 x 1010 1/M; KD = 2.6 x 10-11 M (= 0.03 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human C-reactive protein (CRP), binding is Ca2+ independent
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100147
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/– 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.1 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-4 1/s
    Affinity constant KA = 8.9 x 109 1/M; KD = 1.1 x 10-10 M (= 0.11 nM)

Calprotectin

Calprotectin belongs to the family of S100 proteins and is composed of two subunits S100A8 and S100A9. Increased concentrations are found in response to infections and inflammation.

Calprotectin leaflet

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Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A9 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100460
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.2 – 8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 1.9 x 106 1/Ms
    Dissociation rate constant 9.1 x 10-4 1/s
    Affinity constant KA = 2.0 x 109 1/M; KD = 4.8 x 10-10 M (=0.5 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100468
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 - 7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.8 x 105 1/Ms
    Dissociation rate constant 6.1 x 10-5 1/s
    Affinity constant KA = 7.8 x 109 1/M; KD = 1.3 x 10-10 M (=0.13 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100469
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.2 – 5.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.4 x 105 1/Ms
    Dissociation rate constant 1.5 x 10-4 1/s
    Affinity constant KA = 4.9 x 109 1/M; KD = 2.0 x 10-10 M (=0.2 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8 subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100470
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 - 7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.6 x 105 1/Ms
    Dissociation rate constant 1.1 x 10-4 1/s
    Affinity constant KA = 6.9 x 109 1/M; KD = 1.4 x 10-10 M (=0.14 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes calprotectin S100A8/S100A9 complex
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100618
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 - 7.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.0 x 104 1/Ms
    Dissociation rate constant 5.0 x 10-5 1/s
    Affinity constant KA = 8.0 x 108 1/M; KD = 1.3 x 10-9 M (=1.3 nM)

Recombinant Antigens

IL-6

Interleukin-6 (IL-6) acts as both pro-inflammatory and antiinflammatory cytokine. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer’s Disease, cancer, and rheumatoid arthritis.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100330
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.1 - 7.9
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 3.6 x 104 1/Ms
    Dissociation rate constant 1.5 x 10-5 1/s
    Affinity constant KA = 2.5 x 109 1/M; KD = 4.1 x 10-10 M (=0.41 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100328
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.0 x 105 1/Ms
    Dissociation rate constant 5.6 x 10-5 1/s
    Affinity constant KA = 1.8 x 109 1/M; KD = 5.6 x 10-10 M (=0.56 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-6 (IL-6)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100329
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.5
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant 1.9 x 105 1/Ms
    Dissociation rate constant 1.7 x 10-4 1/s
    Affinity constant KA = 1.1 x 109 1/M; KD = 9.2 x 10-10 M (=0.92 nM)

Recombinant Antigens

IL-8

Interleukin-8 (IL-8) is a chemokine which serves as a chemical signal that attracts neutrophils at the site of inflammation. IL-8 is a promising marker for many clinical conditions with inflammation.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human interleukin-8
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100218
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 3 x 105 1/Ms
    Dissociation rate constant 2 x 10-3 1/s
    Affinity constant KA = 2 x 108 1/M ; KD = 5 x 10-9 M

Lactoferrin

Lactoferrin is an antimicrobial protein, also known as lactotransferrin, which transfers iron to the cells. It is used in fecal testing to detect inflammation in the intestine. Lactoferrin levels are associated with disease severity in inflammatory bowel disease (IBD).

Recombinant Antigens

NGAL

Neutrophil gelatinase-associated lipocalin (NGAL) also known as lipocalin-2, is used as a biomarker of kidney injury, and has also been shown to play a role in cancer and cardiovascular events.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100579
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.4 x 105 1/Ms
    Dissociation rate constant 4.0 x 10-4 1/s
    Affinity constant KA = 1.6 x 109 1/M; KD = 6.3 x 10-10 M (= 0.63 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100580
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.2 x 105 1/Ms
    Dissociation rate constant Does not dissosiate under conditions used
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100581
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 – 6.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.8 x 105 1/Ms
    Dissociation rate constant 3.4 x 10-5 1/s
    Affinity constant KA = 5.3 x 109 1/M; KD = 1.8 x 10-10 M (= 0.18 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neutrophil gelatinase-associated lipocalin (NGAL)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100582
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.6
    Purity ≥ 95 %
    Subclass IgG1Association rate rconstant5.6 x 104 1/Ms
    Association rate constant Not Determined (N/D)
    Dissociation rate constant 4.9 x 10-5 1/s
    Affinity constant KA = 1.2 x 109 1/M; KD = 8.6 x 10-10 M (= 0.86 nM)

PCT

Procalcitonin (PCT) is a precursor protein of the hormone calcitonin, and is associated with systemic infections. In clinical diagnostics, a PCT test is most often used to identify patients with sepsis.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human calcitonin and procalcitonin
    Description Monoclonal antibody raised against human calcitonin. In vitro cultured mouse hybridomas.
    Product code 700020
    Product buffer solution 0.1 M BBS, pH 8, 0.9 % NaCl
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Not Determined (N/D)
    IEF profile 6.0 - 6.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100562
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.8 x 104 1/Ms     
    Dissociation rate constant 2.2 x 10-4 1/s 
    Affinity constant KA = 2.2 x 108 1/M; KD = 4.6 x 10-9 M (=4.6 nM) 
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100563
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 - 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.5 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100564
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 - 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.9 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100567
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.7 x 104 1/Ms
    Dissociation rate constant 3.5 x 10-4 1/s
    Affinity constant KA = 1.9 x 108 1/M; KD = 5.2 x 10-9 M (=5.2 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100769
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 8.2 - 9.1
    Purity ≥ 95 %
    Subclass IgG3
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

Recombinant Antigens

Serum Amyloid A

Serum amyloid A (SAA) is associated with HDL during inflammatory states. The blood level of SAA increases dramatically in response to tissue injury and inflammation.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100279
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.5 – 8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 1.9 x 105 1/Ms
    Dissociation rate constant 1.8 x 10-4 1/s
    Affinity constant KA = 1.0 x 109 1/M; KD = 9.6 x 10-10
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human serum amyloid A (SAA)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100289
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.1 x 105 1/Ms
    Dissociation rate constant 3.0 x 10-4 1/s
    Affinity constant KA = 3.5 x 108 1/M; KD = 2.8 x 10-9 M (= 2.8 nM)

Recombinant Antigens

Transferrin

Transferrin regulates the amount of free iron in circulation. Transferrin concentration elevates in anemia, and can also be used to diagnose other clinical conditions.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100525
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 0.6 x 106 1/Ms
    Dissociation rate constant 1.7 x 10-4 1/s
    Affinity constant KA = 3.8 x 109 1/M; KD = 2.6 x 10-10 M (=0.26 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100440
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 - 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 6.7 x 106 1/Ms
    Dissociation rate constant 1.3 x 10-5 1/s
    Affinity constant KA = 5.3 x 1011 1/M; KD = 1.9 x 10-12 M (=0.002 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human transferrin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100474
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.4 – 8.7
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 2.2 x 106 1/Ms
    Dissociation rate constant 1.1 x 10-4 1/s
    Affinity constant KA = 2.1 x 1010 1/M; KD = 4.8 x 10-11 M (=0.048 nM)

Trypsinogen-2

Trypsinogen-2 is the precursor form of the pancreatic enzyme trypsin. Determination of urine trypsinogen-2 is a useful test to detect acute pancreatitis and to evaluate disease severity.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human trypsinogen-2
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100107
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °CAnalyte descriptionTrypsinogen is the precursor form of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. High serum trypsinogen levels are seen in acute pancreatitis, and cystic fibrosis. Determination of urine trypsinogen-2 is also a useful test to detect acute pancreatitis and to evaluate disease severity.
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 7.6
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.4 x 108 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human trypsinogen-2
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100108
    Product buffer solution 50 mM Na-citrate, pH 7.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.6 x 108 l/mol

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