Support and tools for COVID-19 diagnostics

Discover our reagent solutions for immunological SARS-CoV-2 diagnostic assays

Reagent solutions for immunological SARS-CoV-2 diagnostic assays image

We have a lot of exciting updates we’d like to share with you.

Here’s a preview:

  • Quality is king – the role of high quality raw materials in IVD success
  • An expert guide on antibody and antigen pairings
  • E-book: Driving the future of cardiovascular diagnostics

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Reliable Point-of-Care Testing for SARS-CoV-2 with Rigorously Validated Antibodies

SARS-CoV-2, the virus responsible for COVID-19, has caused around 5 million deaths globally and numbers continue to rise. Point-of-care (POC) testing helps prevent the spread of SARS-CoV-2 by identifying infected individuals to limit their contact with others. However, for POC testing to be effective, it must be able to quickly and accurately detect the virus in patient sample material. Of the different types of POC test used for detecting SARS-CoV-2, antigen tests rely on rigorously validated antibody reagents that can be produced consistently at scale to provide almost instantaneous results.

What types of test are used for detecting SARS-CoV-2?

Two types of test are used for detecting SARS-CoV-2, both of which use patient sample material derived from a throat or nose swab. Nucleic acid-based tests detect viral RNA using RT-PCR and are typically performed by specialized operatives in a centralized laboratory. Antigen tests instead detect viral proteins via a lateral flow immunoassay (LFIA) or an enzyme-linked immunosorbent assay (ELISA). Of the different methodologies available, LFIA enables testing to be performed by non-experts away from the laboratory environment and delivers results within minutes. A further application of both LFIA and ELISA involves detecting anti-SARS-CoV-2 antibodies in the blood to determine whether an individual has previously had COVID-19. Both antigen and antibody tests depend on high-quality antibody reagents to deliver reliable results.

Supporting POC testing for SARS-CoV-2

Antibodies used for detecting SARS-CoV-2 are typically raised against one of the four structural proteins – spike (S), envelope (E), membrane (M) and nucleocapsid (N). Often, two different antibodies that each recognize the same viral protein are used in combination since this approach increases specificity for more accurate results. When identifying antibodies for POC assay development, it is important to select those that are supplied with comprehensive validation data demonstrating selective binding to the intended target. Choosing matched antibody pairs can save time and money as well as helps minimize the risk of generating false positive results.

Medix Biochemica Group offers a broad range of high purity SARS-CoV-2 antibodies for POC testing and continues to expand its product offering as the COVID-19 pandemic unfolds. Antibody validation strategies include assessment of immunoreactivity, sensitivity, and cross-reactivities, as well as detailed kinetic analysis based on biolayer interferometry (BLI). Additionally, testing on patient sample material and provision of matched antibody pairs provides confidence in assay performance, helping bring your product to market sooner.

Medix Biochemica Group is a global, market-leading supplier to the IVD industry. We develop and manufacture critical raw materials including antibodies, antigens, and biologicals, testing many of these with patient sample material to safeguard the performance of your product.

Discuss your needs with one of our team, contact us today by sending your details or email us at moc.acimehcoibxidem@selas.

SARS-CoV-2 related products

We provide a wide selection of SARS-CoV-2 antibodies and recombinant antigens to support the IVD test manufacturers in COVID-19 related assay development. Our R&D team is actively working to develop a recombinant S1 RBD protein from the omicron variant.

Click here and our team will contact you to discuss your project’s unique needs. Or send us a message at moc.acimehcoibxidem@selas.

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SARS-CoV-2 Spike protein antigens >
SARS-CoV-2 Recombinant antigens >
SARS-CoV-2 antibodies >
Serological anti-human IgG, IgM, and IgA antibodies >
Native control proteins and biological specimens >
Covid-19 related biomarkers >

SARS-CoV-2 Recombinant antigens

Recombinant Nucleocapsid antigens

Recombinant Spike S1 antigens

Recombinant Spike S1 RBD antigens

SARS-CoV-2 antibodies

SARS-CoV-2 nucleocapsid antibodies

Recommended pairs

SARS-CoV-2 N

Epitope groups

Epitope groups

 

 

 

The pair recommendations are based on antibodies binding to different epitopes. As nucleoprotein is abundant in the virus, all antibodies pair with themselves and each other.

SARS-CoV-2 RBD antibodies

SARS-CoV-2 Spike 1 antibodies

Native control proteins and biological specimens

We support Covid-19 related test development by providing native control proteins and biological specimens, including:
  • Control material proteins for IgG, IgM and IgA
  • Rheumatoid Factor concentrate used in interference studies
  • Biological products including:
    • COVID-19 cross-reactivity serum/plasma panel
    • COVID-19 confirmed positive & negative serum/plasma samples
    • COVID-19 confirmed positive & negative nasopharyngeal swabs
    • COVID-19 confirmed positive & negative saliva samples
    • Nasal fluid collected prior to November 2019

Please visit www.leebio.com to find more information about these products, or click here and our team will contact you. You can also send us a message at moc.acimehcoibxidem@selas.

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Covid-19 related biomarkers

In conjunction with direct SARS-CoV-2 testing, several biomarkers, such as CRP, SAA, PCT, IL-6, D-dimer and ferritin, can be useful in assessing the disease status of COVID-19 patients. An insightful summary on the current status of Covid-19 research was recently published in Nature Reviews Cardiology: “Cardiac involvement in the long-term implications of COVID-19”. Our most popular and highly recommended monoclonal antibodies and control antigens are listed below.

Please use the quick links below to request a sample or order now.

C-reactive protein
Procalcitonin
Interleukin-6
Ferritin
Serum Amyloid A
D-dimer

Contact us

Click here and our team will contact you to discuss your project’s unique needs:

Contact us

You can also contact us by email: moc.acimehcoibxidem@selas.