MedixMAB™ antibodies & MedixAntigens™

Tumor Markers

MedixMAB™ Tumor markers technical note

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For both diagnostic and therapeutic purposes, cancer markers are being monitored to get an idea about the status of the disease. However, most individual cancer markers are not highly specific, because they are not exclusively expressed and secreted by tumour cells. Therefore, instead of the mere presence of one marker, specificity is often obtained by measuring the levels of a combination of different markers or different forms of the same marker.

AFP

Alpha-fetoprotein (AFP) is a major plasma protein produced by the fetus. AFP is measured in pregnancy as a screening test for a subset of developmental abnormalities. It is also used as a biomarker to detect a subset of tumors.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha1-fetoprotein
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100014
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 - 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 4 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human Alpha1-fetoprotein
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100015
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol

Calcitonin

Calcitonin is a peptide hormone secreted by the thyroid gland. Calcitonin concentrations are increased in patients with medullary thyroid carcinoma (MTC) and can be used to diagnose and monitor the disease.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human calcitonin
    Description Monoclonal antibody raised against human calcitonin. In vitro cultured mouse hybridomas.
    Product code 700019
    Product buffer solution 0.1 M BBS, pH 8, 0.9 % NaCl
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Passed in ELISA when Anti-h Calcitonin antibody 4050 was used as a detection antibody
    IEF profile 6.3 - 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human calcitonin and procalcitonin
    Description Monoclonal antibody raised against human calcitonin. In vitro cultured mouse hybridomas.
    Product code 700020
    Product buffer solution 0.1 M BBS, pH 8, 0.9 % NaCl
    Shelf life and storage 60 months from manufacturing at 2–8 °C
    Product concentration > 1.0 mg/ml
    Immunoreactivity Not Determined (N/D)
    IEF profile 6.0 - 6.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100563
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 - 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.5 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human procalcitonin (PCT)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100564
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 - 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.9 x 104 1/Ms
    Dissociation rate constant Does not dissociate under conditions used
    Affinity constant Not Applicable (N/A)

CA15-3

Cancer antigen 15-3 (CA15-3) is identified through the use of two monoclonal antibodies, one specific for the MUC-1 protein core and another specific for a carbohydrate epitope on the MUC-1 protein. CA15-3 is a widely used serum marker for breast cancer monitoring. Antibodies 4401, 4402, 4403, and 4404 recognize the MUC-1 core protein of CA15-3.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes MUC-1core protein of cancer antigen 15-3
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100591
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 6.6
    Purity ≥ 95 %
    Subclass IgG1, light chain
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes MUC-1core protein of cancer antigen 15-3
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100595
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.6 – 6.7
    Purity ≥ 95 %
    Subclass IgG1, light chain
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes MUC-1core protein of cancer antigen 15-3
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100583
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 6.4
    Purity ≥ 95 %
    Subclass IgG1, light chain
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes MUC-1core protein of cancer antigen 15-3
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100584
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9 - 7.1
    Purity ≥ 95 %
    Subclass IgG1, light chain
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

CA125

Cancer antigen 125 (CA125) is a peptide epitope on the mucin glycoprotein MUC16. CA125 is the most widely used serum biomarker to monitor epithelial ovarian cancer. It is also used for the differential diagnosis of pelvic masses.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cancer antigen 125 (CA125)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100598
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 - 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cancer antigen 125 (CA125)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100628
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 - 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

CA19-9

Carbohydrate antigen 19-9 (CA19-9) is a tumor biomarker also called Sialyl Lewis A. Serum level measurements of CA19-9 are widely used in pancreatic cancer patients for monitoring their response to cancer treatments.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes carbohydrate antigen 19-9 (CA19-9)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100609
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.5 – 8.8
    Purity ≥ 95 %
    Subclass IgG3
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

CEA

Carcinoembryonic antigen (CEA) is normally produced during fetal development. It has been used as a tumor marker for colorectal cancer and several carcinomas.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human carcinoembryonic antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100044
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 5 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human carcinoembryonic antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100428
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human carcinoembryonic antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100047
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 1011 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human carcinoembryonic antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100048
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.5 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human carcinoembryonic antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100049
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 4 x 109 l/mol

CYFRA21-1

CYFRA 21-1 is a fragment of Cytokeratin 19. Serum CYFRA 21-1 has been used as a tumor marker, especially in non-small cell lung cancer.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cytokeratin 19 CYFRA21-1 fragment
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100220
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 6 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human CYFRA21-1 fragment of cytokeratin 19
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100221
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 8.6
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 1 x 104 1/Ms
    Dissociation rate constant 4 x 10-5 1/s
    Affinity constant KA = 3 x 108 1/M, KD = 4 x 10-9 M
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human CYFRA21-1 fragment of cytokeratin 19
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100222
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 - 8.1
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 3 x 104 1/Ms
    Dissociation rate constant 6 x 10-5 1/s
    Affinity constant KA = 5 x 108 1/M, KD = 2 x 10-9 M
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human CYFRA21-1 fragment of cytokeratin 19
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100223
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 5 x 104 1/Ms
    Dissociation rate constant 6 x 10-5 1/s
    Affinity constant KA = 8 x 108 1/M, KD = 1 x 10-9 M

Hemoglobin

Hemoglobin (Hb) is the iron-containing oxygen-transport metalloprotein in red blood cells. Hemoglobin carries oxygen from the lungs to the rest of the body. Deviation from normal values usually indicates abnormalities, such as anemia.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human hemoglobin (A0 and A1 equally well, A2 with lower affinity, and As with very low affinity)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100079
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human hemoglobin (A0, A1 and AS equally well, A2 with low affinity)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100080
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 6 x 108 l/mol

HE4

Human epididymis protein 4 (HE4) is also known as WAP four-disulfide core domain protein 2, and is a 124 amino acid long protease inhibitor. Serum HE4 is often measured together with CA125 to monitor progression of epithelial ovarian cancer after treatment.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human epididymis protein 4 (HE4)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100593
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9 – 7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human epididymis protein 4 (HE4)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100594
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human epididymis protein 4 (HE4)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100589
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human epididymis protein 4 (HE4)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100592
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human epididymis protein 4 (HE4)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100608
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

Inhibin A

Inhibin alpha binds to either beta A or beta B subunit, to form inhibin A, or inhibin B, respectively. Inhibin A tests can be used in the diagnostics of Down syndrome. Inhibin B is a marker of male infertility. Inhibin beta A can form dimers with itself, with inhibin alpha, or inhibin beta B. The dimerization product with inhibin alpha subunit is called inhibin A. Assessment of inhibin A concentration is used in prenatal screening for Down syndrome.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human inhibin alpha subunit
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100711
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 - 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human inhibin beta A subunit, also known as activin beta A.
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100709
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.1 - 8.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/D

NSE

Neuron-specific enolase (NSE) has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrinetumors, and melanoma.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neuron-specific enolase, -isoform
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100388
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 4.3 x 108 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human neuron-specific enolase, -isoform
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100408
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.2 – 8.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 2.2 x 108 l/mol

Pepsinogen I

Pepsinogen (PG I & II) is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount is also released into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100120
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 4 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100093
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 2 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100143
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 4 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100095
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.2 – 8.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 1010 l/mol

Recombinant Antigens

Pepsinogen II

Pepsinogen (PG I & II) is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount is also released into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen II
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100097
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 101o l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen II
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100098
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.2 – 8.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 109 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human pepsinogen II
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100121
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3.5 x 109 l/mol

Recombinant Antigens

PSA

Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. PSA is often elevated in the presence of prostate cancer and in other prostate disorders. Free PSA is a form of PSA that does not become attached to other blood proteins. Decreased levels of free PSA may indicate prostate cancer.

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human prostate-specific antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100102
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.2
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not determined (N/D)
    Dissociation rate constant N/D
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human prostate-specific antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100103
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 – 1.1 mg/ml
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.0 – 7.4
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant Not determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 1010 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human prostate-specific antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100139
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 - 7.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 3 x 109 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human free prostate-specific antigen
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100488
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.9
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.0 x 106 1/Ms
    Dissociation rate constant 1.5 x 10-5 1/s
    Affinity constant KA = 1.3 x 1011 1/M; KD = 7.5 x 10-12 M (=0.0075 nM)

S100B

S100B belongs to the family of dimeric calciumbinding S100 proteins. S100B is a biomarker for traumatic brain injury.

Recombinant Antigens

    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
    Product code 710014
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 100 µl of deionized water
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
    Product code 710045
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 1000 µl of deionized water
    Type Recombinant Antigens
    Description Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
    Product code 710044
    Shelf life and storage -20 °C
    Product concentration 0.5 mg/ml when reconstituted with 2000 µl of deionized water

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