For both diagnostic and therapeutic purposes, cancer markers are being monitored to get an idea about the status of the disease. However, most individual cancer markers are not highly specific, because they are not exclusively expressed and secreted by tumour cells. Therefore, instead of the mere presence of one marker, specificity is often obtained by measuring the levels of a combination of different markers or different forms of the same marker.
Alpha-fetoprotein (AFP) is a major plasma protein produced by the fetus. AFP is measured in pregnancy as a screening test for a subset of developmental abnormalities. It is also used as a biomarker to detect a subset of tumors.
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100015
Product buffer solution
0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
24 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.5 – 7.1
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
3 x 1010 l/mol
Calcitonin
Calcitonin is a peptide hormone secreted by the thyroid gland. Calcitonin concentrations are increased in patients with medullary thyroid carcinoma (MTC) and can be used to diagnose and monitor the disease.
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100564
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
24 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.0 - 6.9
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
2.9 x 104 1/Ms
Dissociation rate constant
Does not dissociate under conditions used
Affinity constant
Not Applicable (N/A)
CA15-3
Cancer antigen 15-3 (CA15-3) is identified through the use of two monoclonal antibodies, one specific for the MUC-1 protein core and another specific for a
carbohydrate epitope on the MUC-1 protein. CA15-3 is a widely used serum marker for breast cancer monitoring.
Antibodies 4401, 4402, 4403, and 4404 recognize the MUC-1 core protein of CA15-3.
Antibody recognizes MUC-1core protein of cancer antigen 15-3
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100584
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
24 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
5.9 - 7.1
Purity
≥ 95 %
Subclass
IgG1, light chain
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
CA125
Cancer antigen 125 (CA125) is a peptide epitope on the mucin glycoprotein MUC16. CA125 is the most widely used serum biomarker to monitor epithelial ovarian cancer. It is also used for the differential diagnosis of pelvic masses.
Antibody recognizes human cancer antigen 125 (CA125)
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100628
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
12 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.3 - 7.3
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
CA19-9
Carbohydrate antigen 19-9 (CA19-9) is a tumor biomarker also called Sialyl Lewis
A. Serum level measurements of CA19-9 are widely used in pancreatic cancer patients for monitoring their response to cancer treatments.
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100609
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
18 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
7.5 – 8.8
Purity
≥ 95 %
Subclass
IgG3
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
CEA
Carcinoembryonic antigen (CEA) is normally produced during fetal development. It has been used as a tumor marker for colorectal cancer and several carcinomas.
Antibody recognizes human CYFRA 21-1 fragment of cytokeratin 19
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100222
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
12 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.5 - 8.1
Purity
≥ 95 %
Subclass
IgG2a
Association rate constant
3 x 104 1/Ms
Dissociation rate constant
6 x 10-5 1/s
Affinity constant
KA = 5 x 108 1/M, KD = 2 x 10-9 M
GDF-15
Growth differentiation factor 15 (GDF-15) is a stress responsive cytokine having elevated expression levels during tissue injury and inflammatory states. Increased GDF-15 levels are associated with cardiovascular diseases such as heart failure and atherosclerosis, and also with chronic kidney disease and cancer.
Antibody recognizes human growth differentiation factor 15 (GDF-15)
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100838
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
Unspecified, storage at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.0–7.2
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
Hemoglobin
Hemoglobin (Hb) is the iron-containing oxygen-transport metalloprotein in red blood cells. Hemoglobin carries oxygen from the lungs to the rest of the body. Deviation from normal values usually indicates abnormalities, such as anemia.
Antibody recognizes human hemoglobin (A0, A1 and AS equally well, A2 with low affinity)
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100080
Product buffer solution
0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
36 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.1 – 6.8
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
6 x 108 l/mol
HE4
Human epididymis protein 4 (HE4) is also known as WAP four-disulfide core
domain protein 2, and is a 124 amino acid long protease inhibitor. Serum HE4 is often measured together with CA125 to monitor progression of epithelial ovarian cancer after treatment.
Antibody recognizes human epididymis protein 4 (HE4)
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100594
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
Unspecified, storage at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
6.2–6.9
Purity
≥ 95 %Kinetic parameters
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
Inhibin A
Inhibin alpha binds to either beta A or beta B subunit, to form inhibin A, or inhibin B, respectively. Inhibin A tests can be used in the diagnostics of Down syndrome.
Inhibin B is a marker of male infertility.
Inhibin beta A can form dimers with itself, with inhibin alpha, or inhibin beta B. The dimerization product with inhibin alpha subunit is called inhibin A. Assessment of inhibin A concentration is used in prenatal screening for Down syndrome.
Antibody recognizes human inhibin beta A subunit, also known as activin beta A.
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100709
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
12 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
7.1 - 8.5
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
Not Determined (N/D)
Dissociation rate constant
N/D
Affinity constant
N/D
NSE
Neuron-specific enolase (NSE) has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer,
carcinoid tumors, pancreatic endocrinetumors, and melanoma.
Recombinant human neuron-specific enolase (NSE) γ-isoform with a C-terminal histidine tag. Predicted molecular weight: 48 kDa.
Product code
610150
Product buffer solution
50 mM Tris-HCl, 150 mM NaCl, 5 mM MgSO4, 0.02 % Tween 20, pH 7.5, 0.095 % NaN3 as a preservative
Shelf life and storage
Unspecified, storage at 2–8 °C
Product concentration
0.5 mg/ml
Pepsinogen I
Pepsinogen (PG I & II) is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount is also released into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities.
Recombinant human pepsinogen I protein. Predicted molecular weight: 40 kDa.
Product code
610000
Shelf life and storage
Unspecified for lyophilized product, storage at 2–8 °C. After reconstitution 2 months at 2–8 °C and 2 months at -20 °C.
Product concentration
0.5 mg/ml when reconstituted with 200 µl of deionized water
Purity
Capillary electrophoresis (CE-SDS)
Pepsinogen II
Pepsinogen (PG I & II) is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount is also released into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities.
Recombinant human pepsinogen II protein. Predicted molecular weight: 41 kDa.
Product code
610001
Shelf life and storage
Unspecified for lyophilized product, storage at 2–8 °C. After reconstitution 3 months at 2–8 °C and 12 months at -20 °C.
Product concentration
0.5 mg/ml when reconstituted with 200 µl of deionized water
Purity
Capillary electrophoresis (CE-SDS)
PSA
Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. PSA is often elevated in the presence of prostate cancer and in other prostate disorders. Free PSA is a form of PSA that does not become attached to other blood proteins. Decreased levels of free PSA may indicate prostate cancer.
Antibody recognizes human free prostate-specific antigen
Description
Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
Product code
100488
Product buffer solution
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Shelf life and storage
18 months from manufacturing at 2–8 °C
Product concentration
5.0 mg/ml (+/- 10 %)
Immunoreactivity
80–120 % compared to the reference sample in an FIA test
IEF profile
5.7 – 6.9
Purity
≥ 95 %
Subclass
IgG1
Association rate constant
2.0 x 106 1/Ms
Dissociation rate constant
1.5 x 10-5 1/s
Affinity constant
KA = 1.3 x 1011 1/M; KD = 7.5 x 10-12 M (=0.0075 nM)
SCC
Squamous cell carcinoma (SCC) antigen is a biomarker of squamous cell carcinomas found in the lung, uterine cervix, esophagus, head, neck, anal canal, and skin.
Squamous cell carcinoma (SCC) antigen is a biomarker of squamous cell carcinomas found in the lung, uterine cervix, esophagus, head, neck, anal canal, and skin.
Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
Product code
710014
Shelf life and storage
-20 °C
Product concentration
0.5 mg/ml when reconstituted with 100 µl of deionized water
Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
Product code
710045
Shelf life and storage
-20 °C
Product concentration
0.5 mg/ml when reconstituted with 1000 µl of deionized water
Recombinant human S100 calcium binding protein B antigen is produced by E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. Predicted molecular weight: 12 kDa.
Product code
710044
Shelf life and storage
-20 °C
Product concentration
0.5 mg/ml when reconstituted with 2000 µl of deionized water
Purity
SDS-PAGE > 90 %
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