Several cardiac markers are currently used in clinical practice to support diagnosis and treatment follow-up related to different CVD. Our Cardiovascular Technical Note presents our most popular cardiac marker antibodies: cTnI, D-dimer, NT-proBNP, myoglobin, ST2 and more, and includes pair recommendations and other essential data to help your reagent validation needs. Technical Note Cardiovascular
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Cardiovascular disease (CVD) is a general term for disorders affecting the heart and blood vessels. It accounts for approximately one third of all deaths globally and is a major contributing factor toward rising healthcare costs. In vitro diagnostic (IVD) assays for detecting cardiac markers are essential tools to help treat or prevent CVD. By enabling clinicians to monitor biomolecules that are released into the blood when the heart is damaged or stressed, IVD assays support diagnosis of conditions including coronary heart disease, cerebrovascular disease, and deep vein thrombosis to guide therapeutic intervention. IVD assay performance and utility hinges on high quality reagents that are available in unlimited supply.

Supporting IVD assay development for cardiac markers

IVD assays can be configured in various formats, with immunoturbidimetry (IT), chemiluminescence immunoassay (CLIA), lateral flow (LF), and fluorescence immunoassay (FIA) being among the most widely used. In many cases, matched antibody pairs are employed for analyte capture and detection since using two antibodies that each recognize a different epitope increases confidence in results.

After marker selection, identifying suitable antibodies – especially matched antibody pairs - can be one of the most time-consuming steps of IVD assay development. For reliable results, antibodies should come with comprehensive validation data showing them to work in the chosen application. Additionally, antibodies should be sourced from a trusted vendor offering the flexibility for custom formulation where applicable and able to guarantee long-term supply. 

Cardiac markers

Medix Biochemica’s CVD marker antibodies are validated for applications including immunoturbidimetry (IT),
chemiluminescence immunoassay (CLIA), lateral flow (LF), and fluorescence immunoassay (FIA).

Cardiac markers - NT-proBNP

MedixMAB NT-proBNP antibodies demonstrate remarkable assay sensitivity that correlates well with the Roche NT-proBNP reference IVD assay.
Antibody pairs include both capture and detection antibodies.

Partnering with an experienced reagent manufacturer with a proven track record in batch-to-batch consistency, delivery accuracy, and scalability is a tried and trusted approach to streamline IVD development. Importantly, a vendor focused on innovation promises to bring your IVD assay to market faster by providing the right raw materials, building quality into validation testing, and streamlining the supply chain, helping ensure urgently-needed tests reach the patients who require them most.

Medix Biochemica Group is a global, market-leading supplier to the IVD industry. We develop, manufacture, and market critical raw materials including antibodies, antigens, and biologicals, many of which are used as components of IVD tests for cardiac marker detection.

Discuss your needs with one of our team, contact us today by sending your details or by contacting us at moc.acimehcoibxidem@xidem.

High-quality bioreagents for cardiac assays

Medix Biochemica Group offers antibodies and antigens for markers commonly utilized to diagnose cardiovascular diseases and monitor patients’ treatment.

When developing your blood-based cardiac immunoassays, you can count on Medix Biochemica reagents for high quality, consistency and supply continuity, enabling you to provide reliable diagnostics solutions to benefit patients with cardiovascular diseases.

Here is a sample of our most popular raw materials for IVD tests:

Antithrombin III (ATIII) – Coagulation marker, with D-dimer

Antigen

CK-MB – important marker for the diagnosis of myocardial infarction

Antibodies
Antigens
Recommended pairs

CRP – high sensity CRP is used to diagnose myocardial infarction

Antibodies
Antigens
Recommended pairs

D-dimer – used to diagnose pulmonary embolism and deep vein thrombosis, and for anticoagulant treatment monitoring

Antibodies
Antigens
Recommended pairs

FABP3 – very early marker for myocardial infarction

Antibodies
Antigen
Recommended pairs

Fibrinogen – Coagulation marker

Antigen

Galectin-3 – prognostic marker for chronic heart failure

Antibodies
Recommended pairs

GDF-15 – associated with heart failure and atherosclerosis

Antibodies
Recommended pairs

HDL – travels around the body and removes fat molecules from cells and delivers them to the liver. Apolipoprotein A1 (ApoA1) is a major component of the high-density lipoprotein (HDL).

Antibodies
Lipoproteins
Recommended pairs

LDL – high levels cause plaque build up in the blood vessels. Apolipoprotein B (ApoB) is the primary apolipoprotein of low-density lipoprotein (LDL)

Antibodies
Antigens

 

 

 

Lp-PLA2 – used as risk marker for cardiovascular disease

Antibodies
Recommended pairs

Myeloperoxidase – biomarker for cardiovascular diseases

Antibodies
Antigen
Recommended pairs

Myoglobin - one of the earliest biomarkers for cardiac injury

Antibodies
Antigens
Recommended pairs

NT-proBNP – widely used heart failure biomaker

Antibodies
Antigens
Recommended pairs

ST2 – new heart failure maker

Antibodies
Recommended pairs

Thrombin – Coagulation marker

Antigens

Troponin I – used in diagnosis of several heart disorders, especially myocardial infarction

Antibodies
Antigen
Recommended pairs

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What are some commonly used cardiac markers?

A broad range of cardiac markers is used to diagnose CVD and direct appropriate treatment. These include:

  • ApoA1 – a major component of the high-density lipoprotein (HDL) that has been suggested to be a better indicator of coronary artery disease than HDL
  • ApoB – the primary apolipoprotein of low-density lipoprotein (LDL), used as a marker for atherosclerosis
  • Copeptin – a cleavage product of pre-provasopressin (preproAVP), that has been proposed as a marker of myocardial infarction and heart failure
  • CK-MB – a dimeric enzyme used for diagnosis of myocardial infarction
  • CRP – an inflammation marker found in the blood; C-reactive protein can be used as an indicator of myocardial infarction
  • D-dimer – a degradation product of crosslinked fibrin, used to diagnose pulmonary embolism and deep vein thrombosis
  • FABP3 – a carrier protein for fatty acids and other lipophilic substances that is used as a diagnostic marker in the early phase of acute myocardial infarction
  • Galectin-3 – a lectin used in assessing the prognosis of patients diagnosed with chronic heart failure
  • GDF-15 – a stress-responsive cytokine used as a marker of heart failure and atherosclerosis
  • Lp-PLA2 – a secreted enzyme produced by inflammatory cells in blood vessels that can be used as a risk marker for CVD
  • Myeloperoxidase – an enzymatic mediator of inflammatory cascades, displaying elevated serum levels in CVD
  • Myoglobin – an intracellular protein that transports oxygen in cardiac and skeletal muscle cells, and one of the earliest markers of cardiac injury
  • proBNP / NT-proBNP – a prohormone and its N-terminal cleavage product that show increased plasma concentrations in patients with heart failure
  • Renin – a proteolytic enzyme secreted by the kidneys, used to diagnose hypertension
  • ST2 – a member of interleukin-1 receptor family, expressed as two isoforms; elevated blood levels of the soluble isoform indicate increased risk for heart failure progression
  • Troponin I / Troponin T – two components of a complex of regulatory proteins (comprising troponin I, T, and C) that are integral to muscle contraction in skeletal and cardiac muscles; serum cardiac troponin tests are often used to help diagnose myocardial infarction