Antibodies and Fab-fragments

Cardiovascular markers

Cardiac biomarkers are a varied group of molecules whose increased concentrations relate to the presence and the risk of future cardiovascular events. Several cardiac markers are currently used in clinical practice to support diagnosis risk assesment, and treatment follow-up related to different CVD pathophysiological processes.

MedixMAB™ Cardiovascular technical note

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Troponin I

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100129
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.1 x 105 1/Ms
    Dissociation rate constant 5.6 x 10-4 1/s
    Affinity constant KA = 0.7 x 109 1/M; KD = 1.4 x 10-9 M (= 1.4 nM)Determination methodSPR analysis (ProteOn XPR36)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100181
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.7 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1.0 x 109
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I (cTnI)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100125
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 1.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 7.0 x 105 1/Ms
    Dissociation rate constant 4.5 x 10-5 1/s
    Affinity constant KA = 1.6 x 1010 1/M; KD = 6.4 x 10-11 M (= 0.064 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I (cTnI)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100180
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.4 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.9 x 106 1/Ms
    Dissociation rate constant 5.8 x 10-6 1/s
    Affinity constant KA = 3.3 x 1011 1/M; KD = 3.0 x 10-12 M (= 0.003 nM)Determination methodSPR analysis (ProteOn XPR36)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I (cTnI)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100523
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.9 – 6.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.8 x 105 1/Ms
    Dissociation rate constant 1.7 x 10-5 1/s     
    Affinity constant KA = 1.6 x 1010 1/M; KD = 5.9 x 10-11 M (= 0.059 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human cardiac troponin I (cTnI)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100524
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.6 – 6.0
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.4 x 105 1/Ms
    Dissociation rate constant 3.5 x 10-5 1/s
    Affinity constant KA = 6.9 x 109 1/M; KD = 1.4 x 10-10 M (= 0.14 nM)Determination methodSPR analysis (ProteOn XPR36)

Fab-fragments

Recombinant Antigens

CK-MB

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human creatine kinase MB isoenzyme
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100630
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 7.0 – 7.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 2 x 109 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human creatine kinase MB isoenzyme
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100086
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 108 l/mol

D-dimer

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100204
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 6 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 8.0
    Purity ≥ 95 %
    Subclass IgG3
    Association rate constant 9 x 104 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100205
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 8.4
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant 1 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100228
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.6
    Purity ≥ 95 %
    Subclass IgG2a
    Association rate constant 2.4 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100479
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.8 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.4 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-Dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100480
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 3.5 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-Dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100481
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.5 – 6.4
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1.3 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)Determination methodSPR analysis (ProteOn XPR36)Determination antigenFDP-D-Dimer, Chrystal Chem Inc. (Lot SDD-1)Cross-reactivitiesNo cross-reactivity against human Fibrinogen, others not tested. EpitopeNot determined (N/D)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human D-dimer
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100482
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 6.7
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.0 x 105 1/Ms
    Dissociation rate constant Does not dissociate
    Affinity constant Not Applicable (N/A)

FABP3

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human fatty acid binding protein 3 (FABP3)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100292
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 18 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.9 – 7.6
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 2.9 x 105 1/Ms
    Dissociation rate constant 4.5 x 10-3 1/s
    Affinity constant KA = 6.5 x 107 1/M; KD = 1.6 x 10-8 M (= 16 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human fatty acid binding protein 3 (FABP3)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100293
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 4.0 x 105 1/Ms
    Dissociation rate constant 1.6 x 10-3 1/s
    Affinity constant KA = 2.5 x 108 1/M; KD = 4.1 x 10-9 M (= 4.1 nM)
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human fatty acid binding protein 3 (FABP3)
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100294
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 3.5 x 105 1/Ms
    Dissociation rate constant 1.2 x 10-4 1/s
    Affinity constant KA = 2.8 x 109 1/M; KD = 3.5 x 10-10 M (= 0.35 nM)

Recombinant Antigens

Myeloperoxidase

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myeloperoxidase
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100266
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.0 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 1 x 106 1/Ms
    Dissociation rate constant 1 x 10-3 1/s
    Affinity constant KD = 1 x 10-9 M; KA = 1 x 109 1/M
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myeloperoxidase
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100267
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.7 – 7.5
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 8 x 105 1/Ms
    Dissociation rate constant 2 x 10-3 1/s
    Affinity constant KD = 2 x 10-9 M; KA = 5 x 108 1/M
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myeloperoxidase
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100268
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % Sulfobetaine, 0.095 % NaN3 as a preservative
    Shelf life and storage 12 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.1 – 6.8
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant 9 x 105 1/Ms
    Dissociation rate constant 2 x 10-4 1/s
    Affinity constant KD = 2 x 10-10 M; KA = 5 x 109 1/M

Myoglobin

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myoglobin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100378
    Product buffer solution 37 mM citrate, 125 mM phosphate, pH 6.0, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.5 – 7.8
    Purity ≥ 95 %
    Subclass IgG2b
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 108 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myoglobin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100354
    Product buffer solution 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 24 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.4 – 6.1
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 7 x 109 l/mol
    Type Monoclonal Antibodies
    Specificity Antibody recognizes human myoglobin
    Description Monoclonal mouse antibody, cultured in vitro under conditions free from animal-derived components
    Product code 100078
    Product buffer solution 50 mM Na-citrate, pH 6.5, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 36 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 5.8 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant Not Determined (N/D)
    Dissociation rate constant N/D
    Affinity constant 1 x 109 l/mol

Recombinant Antigens

NT-proBNP & proBNP

Monoclonal Antibodies

    Type Monoclonal Antibodies
    Specificity Antibody recognizes human N-terminal pro-B-type natriuretic peptide
    Description Monoclonal mouse antibody, cultured in vitro
    Product code 100521
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage 6 months from manufacturing at 2–8 °C
    Product concentration 5.0 mg/ml (+/- 10 %)
    Immunoreactivity 80–120 % compared to the reference sample in an FIA test
    IEF profile 6.3 – 7.3
    Purity ≥ 95 %
    Subclass IgG1
    Association rate constant kA = 7.45 x 105 1/Ms
    Dissociation rate constant kD = 1.70 x 10-4 1/s
    Affinity constant KD = 2.3 x 10-10 M

Fab-fragments

    Type Fab-fragments
    Specificity Fab fragment recognizes human N-terminal pro-B-type natriuretic peptide
    Description Recombinant Fab fragment based on the MedixMAB™ Anti-h NT-proBNP clone 1306. Produced in E.coli and purified chromatographically.
    Product code 600025
    Product buffer solution 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
    Shelf life and storage Unspecified, storage at 2–8 °C
    Product concentration Lot specific
    Immunoreactivity Pass
    Purity ≥ 95 %
    Association rate constant Not determined (N/D)
    Dissociation rate constant N/D
    Affinity constant N/DDetermination method–

Recombinant Antigens